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alt="f[QTQ0" name="main_m61" width="157" height="63" id="main_m61" /></a><br> <a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/kako_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi1','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr01_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr01.gif" alt="NSn00000" width="197" height="55" id="semi1"></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/center_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi2','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr02_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr02_on.gif" alt="/ec00000000" width="183" height="55" id="semi2"></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/toku_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi3','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr03_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr03.gif" alt="/ec0000yr%RO" width="186" height="55" id="semi3"></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/tech_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi4','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr04_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr04.gif" alt="/ec0000000000000" width="185" height="55" id="semi4"></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/kouryu_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi5','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr05_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr05.gif" alt="/ec0000NAmO" width="197" height="55" id="semi5"></a></div> <div class="contents"> <h2>,{103V[[/ec00000000</h2> <br> <div class="center4f"> <font size="5"> Global analysis of long-range genomic interactions that orchestrate lymphocyte cell fate </font> </div> <div class="section"> <h3>o0</h3> <p>Cornelis MurreProfessor of Biological Sciences, University of California, San Diego </p> <h3>e0Bf</h3> <p> s^bt^geg 0 </p> <h3>4X0@b</h3> <p> Wyxvzh0YewT000 <h3>oe</h3> <div class="eng"> It is established that chromatin domains or globules are localized in either transcriptionally repressive or permissive compartments. Here we use genome-wide and computational strategies to characterize chromatin domains during B cell development. We find that domains in the transcriptionally permissive compartment are highly enriched for transcription factor occupancy, euchromatic epigenetic marks, and SINE elements whereas those in repressive compartments are primarily associated with LINE-rich regions. The transcriptionally permissive compartment spatially segregates into distinct sub-compartments, enriched for either H3K27me3 or H3K4me2. We identify distinct classes of anchors, including CTCF and E2A, which act at different length scales and are closely associated with intra-domain and/or inter-domain interactions. We find that relocation of chromatin domains during developmental progression is closely linked with changes in lineage-specific programs of gene expression and large-scale remodeling of chromatin topology. We propose that the repositioning of chromatin domains and changes in domain topology underpin the mechanism by which a B-lineage specific program of gene expression is established.<br> <br> MurreZSXo00bSOzOP[000000k0P}TY00E2A⎙QVP[0zvW00E2Ak0X[(WY00Helix-Loop-Helix00000Y0f0 T[U00~0W0_00Neg0E2Ah0]0n0b6RVP[g0B00IdI{k000@tRSn0xvzg0NLu0000W0f0eg00~0W0_00NVo00ؚ!kgrSOi YSk000B0}ހn0RS6R_k0d0D0f00gen0w00K000Y0O09}NW0f0D0_0`0M0~0Y00<br> Se.sCell 133: 265, 2008, Nat. Immunol. 12: 992, 2011, Nat. Immunol. 13: 1196, 2012<br> <br> #a}HQuSf[0RP[uirf[^ RP[utSf[萀00#~0Ot^Q}2156 </div> <br> <p align="right">00000000000000000uSf[0RP[uirf[^ RP[utSf[萀0[[/ec00000qQP</p> <br> <div style="float:right; margin-right: 170px"> <table border="1" ><tr><td> S0n00000o0'Yf[bZSX zn0h0W0f0[U00f0D0~0Y00</td></tr> </table></div> </p> <br> </div> <table class="foot"> <tr> <td> <a href="JavaScript:history.back();" ><img src="http://wwwcrl.shiga-med.ac.jp/gazou/arrow/prev.gif" alt="" title=""> MRx0</a> </td> <td align="right"><a href="#top">HQ-x0<img src="http://wwwcrl.shiga-med.ac.jp/gazou/arrow/up.gif" alt="" title=""></a> </td> </tr> </table> <address> Copyright (C) <a href="mailto:hqcrl@belle.shiga-med.ac.jp">Central Research Laboratory</a>. All right reserved.since 1996/2/1 <p> Last Updated 2013/11/21</p> </address> </div> </div> </div> </body> </html>