<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01//EN" "http://www.w3.org/TR/html4/strict.dtd"> <html lang="ja"> <head> <title>,{118V/ec00000000</title> <meta http-equiv="Content-Type" content="text/html;charset=shift_jis"> <meta http-equiv="Content-Style-Type" content="text/css"> <link rel="stylesheet" type="text/css" href="http://wwwcrl.shiga-med.ac.jp/css/all.css" media="all"> <style type="text/css"> <!-- p{ color: #555555; font-size:0.95em; } ol{ color: #555555; font-size:0.9em;} ol li{ color: #555555; font-size:1em;} ol p{ color: #555555; font-size:1em; } --> </style> <script type="text/javascript"> function MM_swapImgRestore() { //v3.0 var i,x,a=document.MM_sr; for(i=0;a&&i<a.length&&(x=a[i])&&x.oSrc;i++) x.src=x.oSrc; } function MM_preloadImages() { //v3.0 var d=document; if(d.images){ if(!d.MM_p) d.MM_p=new Array(); var i,j=d.MM_p.length,a=MM_preloadImages.arguments; for(i=0; i<a.length; i++) if (a[i].indexOf("#")!=0){ d.MM_p[j]=new Image; d.MM_p[j++].src=a[i];}} } function MM_findObj(n, d) { //v4.01 var p,i,x; if(!d) d=document; if((p=n.indexOf("?"))>0&&parent.frames.length) { d=parent.frames[n.substring(p+1)].document; n=n.substring(0,p);} if(!(x=d[n])&&d.all) x=d.all[n]; for (i=0;!x&&i<d.forms.length;i++) x=d.forms[i][n]; for(i=0;!x&&d.layers&&i<d.layers.length;i++) x=MM_findObj(n,d.layers[i].document); if(!x && d.getElementById) x=d.getElementById(n); return x; } function MM_swapImage() { //v3.0 var i,j=0,x,a=MM_swapImage.arguments; document.MM_sr=new Array; for(i=0;i<(a.length-2);i+=3) if ((x=MM_findObj(a[i]))!=null){document.MM_sr[j++]=x; if(!x.oSrc) x.oSrc=x.src; x.src=a[i+2];} } </script> </head> <body onLoad="MM_preloadImages('http://wwwcrl.shiga-med.ac.jp/common/images/mini_link01_on.gif','http://wwwcrl.shiga-med.ac.jp/common/images/mini_link02_on.gif','http://wwwcrl.shiga-med.ac.jp/common/images/mini_link03_on.gif','http://wwwcrl.shiga-med.ac.jp/common/images/mini_link04_on.gif','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu01_on.png','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu02_on.png','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu03_on.png','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu04_on.png','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu05_on.png','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu06_on.png','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr01_on.gif','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr02_on.gif','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr03_on.gif','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr04_on.gif','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr05_on.gif')"> <a name="top"></a><div class="container"> <div id="header"> <div class="b_left"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/shiga_med_logo.png" alt="n;Sy'Yf[" width="170" height="51" /><img src="http://wwwcrl.shiga-med.ac.jp/common/images/crl_bnr.png" width="810" height="95" alt="VzlNn;Sy'Yf[[[/ec0000" /><img src="http://wwwcrl.shiga-med.ac.jp/common/images/logo_underbar.gif" width="810" height="11" alt="Vz'Yf[lNn;Sy'Yf[[[/ec00000Central Reseach Laboratory Shiga University of Medical Science" /></div> </div> <div class="b_right"><a href="http://wwwcrl.shiga-med.ac.jp/index.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('mini_m11','','http://wwwcrl.shiga-med.ac.jp/common/images/mini_link01_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/mini_link01.gif" alt="TOP000k0;b0" name="mini_m11" width="140" height="51" id="mini_m11" /></a><a href="http://wwwcrl.shiga-med.ac.jp/home/search/search.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('mini_m21','','http://wwwcrl.shiga-med.ac.jp/common/images/mini_link02_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/mini_link02.gif" alt="000Q0i"}Y00" width="140" height="35" id="mini_m21" /></a><a href="http://wwwcrl.shiga-med.ac.jp/home/sitemap/sitemap.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('mini_m31','','http://wwwcrl.shiga-med.ac.jp/common/images/mini_link03_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/mini_link03.gif" alt="000000" width="140" height="33" id="mini_m31" /></a><a href="http://wwwcrl.shiga-med.ac.jp/home/link/link.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('mini_m41','','http://wwwcrl.shiga-med.ac.jp/common/images/mini_link04_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/mini_link04.gif" alt="000" width="140" height="38" id="mini_m41" /></a></div> <div id="title"><a href="http://wwwcrl.shiga-med.ac.jp/home/kiki_bumon/kiki_bumon.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('main_m11','','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu01_on.png',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/main_menu01.png" alt="_jhV萀" name="main_m11" width="160" height="63" id="main_m11" /></a><a href="http://wwwcrl.shiga-med.ac.jp/home/ri_bumon/home.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('main_m21','','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu02_on.png',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/main_menu02.png" alt="RI萀" name="main_m21" width="159" height="63" id="main_m21" /></a><a href="http://wwwcrl.shiga-med.ac.jp/home/haichizu/haichizu.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('main_m31','','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu03_on.png',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/main_menu03.png" alt="MnV" name="main_m31" width="159" height="63" id="main_m31" /></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/seminar.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('main_m41','','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu04_on.png',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/main_menu04_on.png" alt="0000" name="main_m41" width="158" height="63" id="main_m41" /></a><a href="http://wwwcrl.shiga-med.ac.jp/home/sangakurenkei/sangakurenkei.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('main_m51','','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu05_on.png',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/main_menu05.png" alt="#uf[#:d" name="main_m51" width="157" height="63" id="main_m51" /></a><a href="http://gakucrl.shiga-med.ac.jp/gakunai/gakunai/index.html" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('main_m61','','http://wwwcrl.shiga-med.ac.jp/common/images/main_menu06_on.png',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/images/main_menu06.png" alt="f[QTQ0" name="main_m61" width="157" height="63" id="main_m61" /></a><br> <a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/kako_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi1','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr01_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr01.gif" alt="NSn00000" width="197" height="55" id="semi1"></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/center_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi2','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr02_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr02_on.gif" alt="/ec00000000" width="183" height="55" id="semi2"></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/toku_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi3','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr03_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr03.gif" alt="/ec0000yr%RO" width="186" height="55" id="semi3"></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/tech_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi4','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr04_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr04.gif" alt="/ec0000000000000" width="185" height="55" id="semi4"></a><a href="http://wwwcrl.shiga-med.ac.jp/home/seminar/kouryu_semi.html" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('semi5','','http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr05_on.gif',1)"><img src="http://wwwcrl.shiga-med.ac.jp/common/sub_bnr_img/seminar_bnr05.gif" alt="/ec0000NAmO" width="197" height="55" id="semi5"></a></div> <div class="contents"> <h2>,{118V[[/ec00000000</h2> <br> <div class="center4f"> <font size="5"> ,{VVRf[0000<br> xQ0}̃So0i0n00F0k0DOHaD (Developmental Origins of Health and Disease) k00c0f0D00K0 </font> <h3>o0</h3> <p>QQg0^[Gastroenterology and Mucosal immunology, University of Bern, Switzerland </p> <h3>e0Bf</h3> <p> s^bt^geё 0 </p> <h3>4X0@b</h3> <p> Wyxvzh0YewT000 </p> <h3>oe</h3> <p> 0b0n0x{g0o00h }n0SOQx0n0Rsvj0S000]0W0f00 g[j00}̃00000n0ne00 TBfk0bW0BR0j0Q00p0j00j0D00S0n0S0h0k0W0f00\j0O0h003d0n0xQ0}̃Sn0y_rRL0w00f0D000,{1juvk00[;Nk0T'`n0B00xQ0}̃SL00[;Nn0MQu|0YeW00 g[j00}̃00000k0[W0f00MQu|L0yrpuvk0S_g0M000F0k0Y00S0h00,{2juvk00xQ0}̃L00'Yxk000Wt Ng0g0ؚ[^h00001gS__001010-1011n0[^g0 h0d0O0S0h0g00 g[j00}̃n0Xk02D0g0D00S0h00]0W0f00,{3juvk00xQ0}̃SL00ꁫn0cd0S8huiryr gn0NL}0Oc0f00[;Nk0 g(uj000000wxj0i00\O0QW0f0D00S0h0g0B000<br> 0b0TsN^o00kn0!q̃n0P[[Qg0΀PQh0W0f0d00΀PQn0x{k0gRk0h0d0O00}̃o00Q#uBfk00kn0#uSk0uo`Y000}̃g0B00S0h0L0w00f0D000]0W0f00|^PQn0zvh0qQk00xQ0}̃S00[[W0_00}̃Sk0zvTY00S0h0L0:yU00f0D000<br> 0b0n0xvz[g0o00!q̃000h00S00k0Svk0[@wSj0'Yx̃*h0OD00Y Z000k00NNvk0'Yx̃*h0[@wU0[00΀PQ000n0MQu|n0zvT0y00xvz0Lc0_00S0n0xvzk0J0D0f00NNvk0'Yx̃*hL0[@wW0_0Y Z000K00u~00_0΀PQ000g0o00000000k0ky00MQu|L000zvTW0f0J0000}̃bb'`k0Y00zOP[n0zvs0ؚO0j0c0f0D00S0h0L0:yU00_0 (Gomez de Agero et al. Science 2016)0S0n0xvzk0J0D0f00uM0_00}̃o0P[[Qn0΀PQk00RTW0j0D0L00'Yx̃1uegn0NirL00΀PQk00RTW00΀PQn0MQu|n0zvT0RQ0f0D00S0h0L0:yUU00_00S000n0wo00kSOn0xQ0}̃So00΀PQL0P[[Qk0D00Bfpg0ek00΀PQn0MQu|n0zvT0RQ0f0D00S0h00:yW0f0D000<br> 0yo00 Nn0֊eg0O00f0D00p }130Oc0_0'Yx̃Nirn0xvz00bN0000(uD0f0xvzW0f0M0~0W0_00Y Z000x0n0NNvj0'Yx̃[@wn0΀PQk0[Y00q_k0ky0f00bN000k0[Y00NNvj0'Yx̃[@wn0q_o00zOP[zvsn0 YS0+T0f00\U0D00F0g0Y00S000n0wo00xQ0}̃SL00[;Nn0zvuRgk0000'YM0j0 NSvj0q_0NH0f0D00S0h00:yW0f0J000DOHaDk0J0Q00xQ0}̃Sn0͑'`0:yW0f0D0~0Y00NVn00000g0o00TsN^zvuRgk0J0Q00k0xQ0}̃Sn0͑'`0/ecY00Nn0~^d0K0n0xvz09}NW0_0D0h0H0f0D0~0Y00<br> <br> <div class="eng"> <font size="+0.5"> Efficient incorporation of nutrients into our body, and prevention of microbes migration into our body are both critical in our intestine. We know at least three roles of gut microbiota for these critical intestinal functions. At first, healthy gut microbiota educates host immune system to react specifically with harmful bacteria and viruses. At second, gut microbiota colonizes up to 1010-1011 per gram in the large intestine. This bacterial density is known to be one of the densest bacterial colonization on the earth. These dense bacteria prevent harmful bacteria to proliferate in the large intestine. At third, gut microbes have their own unique prokaryotic metabolic pathways. These metabolic pathways synthesize Vitamins, short chain fatty acids, and other useful metabolites to the host.<br> Since we are mammals, we grow in mother s sterile womb during early development. We first encounter live bacteria at mother s birth canal. The bacteria in the birth canal are the first colonizers of neonatal guts. Since then, the neonatal gut microbiota grow and become stable as we grow to become adult.<br> In my laboratory, we examined the effect of bacterial colonization during pregnancy for the development of immune system of their fetus. The experiment was done with germ-free mice and a reversible bacterial colonization strain Escherichia coli HA107. Fetus from transiently bacterial colonized mother showed stronger protection phenotype to bacteria compared to control mice (Gomez de Agero et al. Science 2016). Although we did not observe migration of live bacteria to the fetus, we observed migration of bacterial metabolites to the fetus. These findings suggest that bacterial metabolites from mother s gut microbiota can help to develop immune system of their fetus even before birth. <br> I have been working on the Carbon-13 labeled E. coli metabolomics, which contributed to the metabolomics study of pregnant mice and their fetus. As my main project, I am focusing on a metabolomics study of adult mice. The irreversible effects on adult mice from transient bacterial colonization seemed to be smaller than those on fetus during pregnancy. These findings suggest the importance of gut microbiota in DOHaD. In this seminar, I also would like to introduce some other reports that support the importance of gut microbiota in DOHaD. </font> </div> <p align="right">000000000000000000000000000VRf[^0[[/ec00000qQP <br><br><br> <div style="float:right; margin-right: 140px"> <table border="1" ><tr><td> 0,g0000o00'Yf[bZSX z 0;Sf[}Tyr֊ 0n0[0000g0Y00</td></tr> </table></div> </p> <br> </div> <table class="foot"> <tr> <td> <a href="JavaScript:history.back();" ><img src="http://wwwcrl.shiga-med.ac.jp/gazou/arrow/prev.gif" alt="" title=""> MRx0</a> </td> <td align="right"><a href="#top">HQ-x0<img src="http://wwwcrl.shiga-med.ac.jp/gazou/arrow/up.gif" alt="" title=""></a> </td> </tr> </table> <address> Copyright (C) <a href="mailto:hqcrl@belle.shiga-med.ac.jp">Central Research Laboratory</a>. All right reserved.since 1996/2/1 <p> Last Updated 2016/10/</p> </address> </div> </body> </html>