਍ഀ ਍ഀ ਍ഀ 第124回支援センターセミナー਍ഀ ਍ഀ ਍ഀ ਍ഀ ਍ഀ ਍ഀ ਍ഀ ਍ഀ ਍ഀ
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機器部門RI部門配置図セミナー産学連携学内向け
਍ഀ 過去のセミナー支援センターセミナー支援センター特別講習会支援センターテクニカルセミナー支援センター交流会
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第124回実験実習支援センターセミナー

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਍ഀ ਍ഀ The role of microbial amyloid in neurodegeneration
਍ഀ (神経変性における細菌由来アミロイドの役割)਍ഀ ਍ഀ
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演 者

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਍ഀ Robert P. Friedland, MD(ルイビル大学医学部神経内科学講座教授)਍ഀ

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日 時

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਍ഀ 平成30年2月28日(水)16:00〜਍ഀ

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場 所

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਍ഀ 基礎研究棟2階 教職員ロビー਍ഀ

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講演要旨

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਍ഀ It has become apparent that the intestinal microbiota orchestrate important aspects of our metabolism, immunity and development. Recent work has demonstrated that the microbiota also influence brain function in healthy and diseased individuals. Of great interest are reports that intestinal bacteria play a role in the pathogenic cascade of both Parkinson's and Alzheimer's diseases. Recent work also suggests that inflammasome activation may be the cause of amyloid beta aggregation in Alzheimer's disease. Neurodegenerative disorders involve misfolding of endogenous proteins which spreads from one region of the body to another in a manner analogous to prions. Sterile neuroinflammation is also observed. The mechanisms of how the microbiota influences disease requires elaboration. Microbial proteins or metabolites may influence neurodegeneration through promotion of amyloid formation by human proteins or by enhancing inflammatory responses to endogenous neuronal amyloids. Current knowledge concerning bacterial amyloids illustrates their potential to influence cerebral amyloid aggregation as well as neuroinflammation. The term “mapranosis” is proposed to describe microbiota-associated proteopathy and neuroinflammation. The study of amyloid proteins made by the microbiota and their influence on health and disease is in its infancy. This is a promising area for therapeutic intervention, as there are many ways to alter our microbial partners and their products, including amyloid proteins.਍ഀ
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神経難病研究センター神経診断治療学部門・実験実習支援センター 共催

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਍ഀ  本セミナーは、大学院博士課程「医学総合特論਍渰贰骊뭛쨰ﰰ朰夰0㰰⼀琀搀㸀㰀⼀琀爀㸀ഀ ਍㰀⼀琀愀戀氀攀㸀ഀ ਍㰀⼀搀椀瘀㸀ഀ ਍㰀戀爀㸀ഀ ਍ഀ ਍㰀琀愀戀氀攀 挀氀愀猀猀㴀∀昀漀漀琀∀㸀ഀ ਍㰀琀爀㸀ഀ ਍㰀琀搀㸀ഀ ਍㰀愀 栀爀攀昀㴀∀䨀愀瘀愀匀挀爀椀瀀琀㨀栀椀猀琀漀爀礀⸀戀愀挀欀⠀⤀㬀∀ 㸀㰀椀洀最 猀爀挀㴀∀栀琀琀瀀㨀⼀⼀眀眀眀挀爀氀⸀猀栀椀最愀ⴀ洀攀搀⸀愀挀⸀樀瀀⼀最愀稀漀甀⼀愀爀爀漀眀⼀瀀爀攀瘀⸀最椀昀∀ 愀氀琀㴀∀∀ 琀椀琀氀攀㴀∀∀㸀 䴀硒㰰⼀愀㸀ഀ ਍㰀⼀琀搀㸀ഀ ਍㰀琀搀 愀氀椀最渀㴀∀爀椀最栀琀∀㸀㰀愀 栀爀攀昀㴀∀⌀琀漀瀀∀㸀䠀ⵑ碘㰰椀洀最 猀爀挀㴀∀栀琀琀瀀㨀⼀⼀眀眀眀挀爀氀⸀猀栀椀最愀ⴀ洀攀搀⸀愀挀⸀樀瀀⼀最愀稀漀甀⼀愀爀爀漀眀⼀甀瀀⸀最椀昀∀ 愀氀琀㴀∀∀ 琀椀琀氀攀㴀∀∀㸀㰀⼀愀㸀ഀ ਍㰀⼀琀搀㸀ഀ ਍㰀⼀琀爀㸀ഀ ਍㰀⼀琀愀戀氀攀㸀ഀ ਍㰀愀搀搀爀攀猀猀㸀ഀ ਍䌀漀瀀礀爀椀最栀琀 ⠀䌀⤀ 㰀愀 栀爀攀昀㴀∀洀愀椀氀琀漀㨀栀焀挀爀氀䀀戀攀氀氀攀⸀猀栀椀最愀ⴀ洀攀搀⸀愀挀⸀樀瀀∀㸀䌀攀渀琀爀愀氀 刀攀猀攀愀爀挀栀 䰀愀戀漀爀愀琀漀爀礀㰀⼀愀㸀⸀ 䄀氀氀 爀椀最栀琀 爀攀猀攀爀瘀攀搀⸀猀椀渀挀攀 ㄀㤀㤀㘀⼀㈀⼀㄀ഀ ਍㰀瀀㸀 䰀愀猀琀 唀瀀搀愀琀攀搀 ㈀ ㄀㠀⼀㈀⼀㘀㰀⼀瀀㸀ഀ ਍㰀⼀愀搀搀爀攀猀猀㸀ഀ ਍ഀ ਍㰀⼀搀椀瘀㸀ഀ ਍㰀⼀戀漀搀礀㸀ഀ ਍㰀⼀栀琀洀氀㸀ഀ ਍