演　者

Professor James McLarnon
Department of Pharmacology & Therapeutics, University of British Columbia

日　時

平成１５年３月１０日（月）１６時００分から

場　所

基礎研究棟２階　教官ロビー

＜James McLarnon Laboratoryの紹介＞

My laboratory studies the biophysical properties and signaling mechanisms in human microglia, the immuneresponding cells of the brain. This work is designed to better understand how microglia respond to inflammatorystimuli such as cytokines, chemokines, β-amyloid and other agents such as ATP and PAF and to elucidate thenature of cellular functional responses such as enhanced expression and production of factors including oneswith neurotoxic potential. Imaging of calcium and other putative signaling agents is combined with patch clampelectrophysiology to study stimulus-induced cellular signaling mechanisms and RT-PCR and ELISA assaysare used to examine cellular output processes. Pharmacological manipulation of microglial signaling pathwaysmay prove effective in modulation of inflammatory responses in the brain in neurodegenerative diseasesand stroke.

分子神経科学研究センター　共 催